Our family began using bioregulators in 2015 and have found them more beneficial than we expected. After meeting with their key researchers and learning the science behind them, we’ve come to understand their remarkable potential. This article provides an overview of how bioregulators work and what they can help achieve.
Bioregulators are short-chain amino acids of two, three or four peptides that interact with DNA to activate the body’s natural repair systems. They promote tissue regeneration and organ repair, slowing ageing and supporting overall health.
Bioregulators work by interacting with DNA and histone proteins to stimulate cell repair and tissue regeneration. Once ingested, they travel to the specific target organs, where they act as signalling molecules, helping to modulate and restore organ function.
They help activate telomerase, the enzyme that maintains telomere length, allowing cells to divide for longer periods. As molecular biologist and gerontologist William Andrews says, “Every time our cells divide, our telomeres get a little shorter, and every time they shorten, our cells age.” This activation delays the ageing process and improves cellular health.
Bioregulators also enhance DNA methylation, a crucial process that affects gene expression. This means they can help regulate genes involved in ageing and disease, offering a valuable way to boost overall health for anyone over 35 or with a system that needs support.
The most significant benefit of bioregulators is their ability to target ageing at the cellular level. As we age, organs and tissues become less efficient, leading to age-related conditions such as heart disease, cognitive decline, and weakened immunity. Bioregulators help restore the function of these systems by supporting telomere health, DNA repair, and tissue regeneration.
Key benefits include:
Supporting telomere health: Bioregulators promote telomerase activity, which helps maintain telomere length. Longer telomeres are linked to slower ageing and a reduced risk of age-related diseases. According to Dr Steven Horvath, the human genetics UCLA scientist who created the Horvath epigenetic clock, "Ageing eight or more years faster than your calendar age equates to twice the typical risk of dying while ageing seven years slower is associated with half the risk of death.”
Enhancing tissue regeneration: Bioregulators improve the body’s ability to repair damaged tissues by stimulating protein production. This leads to faster recovery and helps prevent tissue degeneration.
Improving organ function: Each bioregulator targets specific organs, such as the heart, liver, thyroid, and retina, modulating their function. For example, bioregulators have shown promising results in improving vision health, particularly in older adults at risk of retinal degeneration, diabetic retinopathy, retinitis pigmentosa and age-related macular degeneration. A study led by Dr Vladimir Khavinson and his colleagues in 2009 demonstrated how retinal peptides help slow vision loss by supporting the health of cone and rod cells.
Optimising immune response: Bioregulators like thymus and bone marrow help restore immune system function, strengthening the body’s ability to fight off infections and diseases, which is especially important as immunity weakens with age.
Reducing biological age: Dr Bill Lawrence’s studies have shown that bioregulators can reduce biological age by up to 56 years by enhancing telomere length and DNA methylation patterns.
The origins of bioregulator research can be traced back to the work of Ivan Pavlov, who received the Nobel Prize in 1904 for his studies on amino acids and gastrointestinal physiology. Building on this foundation, Dr Vladimir Khavinson developed peptide bioregulators in the 1980s, initially aimed at restoring organ function in older adults.
Dr Khavinson's work spans over four decades and includes research on thousands of participants, showing how bioregulators regulate gene expression, stimulate tissue regeneration and rejuvenate ageing organs. In both animal and human studies, peptide bioregulators have been shown to extend lifespan by 20-40%, bringing them close to their species-specific lifespan limits.
Dr Khavinson authored more than 700 scientific publications and 27 monographs. His work includes the book Peptides in the Epigenetic Control of Ageing (Khavinson, Micans, & Maryanovich), which summarises how peptides can regulate gene expression, increase telomere length, and support tissue repair and cell proliferation.
Dr Khavinson’s research has also been applied in extreme environments. A large-scale study of 11,000 Gazprom workers operating in Siberia showed that those taking bioregulators experienced 2.8 times fewer illnesses than those who didn’t.
Russian cosmonauts and elite military units, such as submariners, have benefited from their ability to enhance resilience, while Russian athletes have used peptide bioregulators for recovery and rehabilitation since the 1980s, mainly targeting the heart, brain, and cartilage.
Inspired by Khavinson’s findings, Dr Bill Lawrence has been conducting comprehensive trials in the United States since 2017, focusing on the effects of bioregulators on biological age. His studies involve the full 21 bioregulators tested on 180 participants, emphasising telomere length and DNA methylation, two critical markers of ageing.
Results from Dr Lawrence’s Telomerase Activation Protocol (TAP) study revealed that over 90% of participants met their telomere-lengthening goals within three years. They reduced their telomere age by up to 22 years within three years and up to 56 years within nine years.
Dr Lawrence’s Epigenetic Methylation Study (EMS) showed a five-year reduction in participants' epigenetic age, correlating with a 25-56% reduction in all-cause mortality risk.
We recently interviewed Dr Lawrence and some of his trial participants, and their testimony matches the studies reporting improvements in physical health and enhanced cognitive function, energy levels, and sleep quality.
The potential of bioregulators is well-documented in worldwide studies and trials. Notable institutions involved in researching peptide bioregulators include the National Institute on Aging (Baltimore, MD), the Italian National Research Centre on Ageing (Ancona, Italy), the Institute of Anatomy at Ludwig-Maximilians University (Munich, Germany), the Prince Felipe Research Center (Valencia, Spain), and the University of Antwerp (Belgium).
Clinical studies confirm that these short amino acid chains regulate the functional activity, proliferation, apoptosis (cell death), and differentiation of cells in humans, animals, and even plants.
Unlike traditional supplements, bioregulators are typically taken in cycles, allowing the body to regulate naturally without becoming dependent. Tested on thousands of individuals, bioregulators have shown no side effects or contraindications, making them a safe, natural alternative to invasive treatments like stem cell therapy.
Khavinson’s bioregulator peptides are now manufactured in the UK as Nature’s Marvels, and we are authorised UK retailers. They comprise 21 organs covering every major bodily system: cardiovascular, immune, respiratory, urinary, reproductive, digestive, endocrine, nervous, and locomotive.
We offer 1-1 consultations to choose the most suitable combination of bioregulators, a free planner to track your intake, and free tracked delivery straight from the manufacturing plant. Contact us for more information.
Bioregulators offer a safe way of addressing the root causes of age-related decline by promoting cellular repair, restoring telomere length, and regulating DNA.
We already know that lifestyle interventions like caloric restriction, moderate exercise, and quality sleep can improve health, so it’s exciting to have access to a natural supplement that helps repair at the cellular and organ level.
For those looking to extend their lifespan and improve their health, bioregulators provide an affordable, natural alternative to costly and invasive treatments like stem cell therapy.
Comments will be approved before showing up.
Tracked & signed
Orders over £35
Orders over £199
Soil Association certified
Chat, email or call
for the Ageless Team
Author
A mighty team of natural health researchers led by Daniel Perez Vidal. We follow strict selection criteria and test everything we retail, from ground-breaking food supplements to natural skincare products. Our main area of expertise is CBD.